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The CBS Films project centres on a broody single woman who uses artificial insemination to conceive twins. Her life is complicated when she meets the man of her dreams on the same day.
One of Poul's first tasks on the movie will be to find a leading man to star opposite Lopez.
Kate Angelo penned the film, which begins production in May for a January 2010 release.
Plan B will be Poul's first feature film. He has directed episodes of Big Love, Six Feet Under and Rome.
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