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Oscar-winner Forest Whitaker was originally tapped to play the part, but he was forced to walk away when a month-long shooting delay interfered with his other commitments, Ain't It Cool News reports.
The Expendables is written and directed by Stallone. He also stars in the film along with Mickey Rourke, Jason Statham and Jet Li.
Responding to criticism of the switch, he said: "The anger of the casting of 50 Cent is understandable, but not fair.
"If a man can communicate in one medium, he can communicate in another if his strengths are brought out and he has the support of well-wishers. So, trust me, the change from Forest Whitaker to 50 Cent is a good one."
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