Speaking to Fearnet, the actor admitted that director McG had approached him about the possibility of reprising the cult character for a rumoured sequel to this summer's Terminator Salvation.
"I’m interested. I was listening to him tell me about it... We saw each other and he talked to me about it, so we’ll see what happens," he said.
"The sci-fi genre, and specifically that character, is something I’m very proud of. It’s what broke me out big to the world."
McG had previously suggested bringing Patrick back as a "cell replication" scientist, saying: "Imagine seeing a 60-year-old Robert Patrick and knowing, 'Holy s**t! That's gonna be the T-1000, who comes back perfect, lean and the whole thing'."
Discussing McG's contribution to the franchise, Patrick said: "I certainly can’t think of anybody to tackle T4 other than him right now. I think he’s got the energy for it and the passion for it.
"I know he’s a fan of the movies. I think he’ll do a fantastic job. I’m interested to see what Christian Bale does with John Connor. I’m interested to see the whole setting for that. It’s a fantastic franchise."
Terminator Salvation is released in the US on May 21 and the UK on June 3.