The actor, who co-wrote and starred in the '80s sci-fi comedies, told The Guardian: "There'll be a whole new generation that has to be trained and a leader that you'll all love when you meet her."
The 56-year-old recently disclosed his wish to see Eliza Dushku and Alyssa Milano, who lends her voice to the new Ghostbusters video game, suit up in the upcoming sequel.
According to Aykroyd, Ghostbusters 3 will involve the new recruits "learning how to use the neuron splitter and the inter-planet interceptor - new tools to enable them to slip from dimension to dimension".
The Office duo Lee Eisenberg and Gene Stupnitsky are working on the script for Ghostbusters 3, with actor and filmmaker Harold Ramis (Egon Spengler in the first two movies) linked to the director's chair.
> DS Fantasies: The new 'Ghostbusters'