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Speaking to The Guardian, the filmmaker revealed that his confrontation with Murray came when the pair were working together on Charlie's Angels.
"I don't think there's been a film I've made where there hasn't been some kind of physical fight," he said. "I mean, I've been headbutted by an A-list star. Square in the head. An inch later and my nose would have been obliterated."
Pressed to disclose the identity of the actor, McG replied: "I probably shouldn't. But it was Bill Murray. Y'know, it's a passionate industry."
Murray portrayed Bosley in the 2000 Charlie's Angels adaptation, but was replaced by Bernie Mac in sequel Full Throttle.
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