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According to Forbes magazine, the 66-year-old earned a salary of £43.3 million to reprise his iconic role in Indiana Jones And The Kingdom Of The Crystal Skull.
Ford received his massive paycheck as a result of a deal with director Steven Spielberg, which saw him entitled to a share of profits.
The movie grossed more than £500 million at the worldwide box office and is currently the 23rd most successful film of all time.
Adam Sandler was named the second highest-paid actor, pocketing £36.6 million from Don't Mess With The Zohan and Bedtime Stories, while Will Smith was placed third with Hancock and Seven Pounds giving him earnings of £30 million.
The only British star in the top 20 was Christian Bale with an estimated £6.6 million, although Forbes predicted that he will break into the top ten in next year's list thanks to Terminator Salvation and the upcoming Public Enemies.
Earnings were calculated by talking to lawyers, agents and producers. The eligibility period was June 2008 to June 2009 and sponsorship deals and advertising contracts were also considered.
The top ten highest-paid actors are:
1. Harrison Ford (£43.3m)
2. Adam Sandler (£36.6m)
3. Will Smith (£30m)
4. Eddie Murphy (£26.6m)
5. Nicolas Cage (£26.6m)
6. Tom Hanks (£23.3m)
7. Tom Cruise (£20m)
8. Jim Carrey (£18.6m)
8. Brad Pitt (£18.6m)
8. Johnny Depp (£18.6m)
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