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The actress revealed in an interview with TV Squad that she will not reteam with original cast members Bill Murray, Dan Aykroyd and Harold Ramis to portray Dana Barrett for the forthcoming update, SciFiSquad.com reports.
She said: "No, I don't expect to have anything to do with it, although I wish them well. I just did a benefit with Bill and we love working together, but I think they're trying to create something new completely with the Ghostbusters, although I know Bill is in it.
"I hope my little son Oscar [from Ghostbusters II] is a Ghostbuster!"
Weaver also passed on lending her voice to the recently released video game based on the 1984 film.
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