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The 27 Dresses actress has been cast as a woman who is named as a joint guardian for her friends' daughter when the couple die in a car crash.
Greg Berlanti (TV's Brothers And Sisters) will direct from a script by Ian Deitchman and Kristin Rusk Robinson.
Barry Josephson and Paul Brooks are producing Life As We Know It, with Heigl and her mother Nancy Heigl serving as executive producers.
Heigl can next be seen in romcom The Ugly Truth opposite Gerard Butler.
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