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The filmmaker signed on in January to update the Jules Verne novel that was turned into a classic 1954 Disney movie featuring James Mason as the captain of the Nautilus submarine.
The Terminator Salvation helmer had previously suggested that he was hoping actor Will Smith would take on the role for his origin picture.
However, McG told IGN that he would love to reteam with Worthington, who co-starred with Christian Bale in the recent sci-fi blockbuster.
He said: "I take a lot of satisfaction in playing a role in breaking the great Sam Worthington, who I think is one of the best actors out there. He's all over the place, and I might cast him as Nemo if it's in the cards. We'll see."
McG is also attached to direct the film adaptation of stage musical Spring Awakening.
Movie Reviews
'Extremely Loud & Incredibly Close' reviewTom Hanks features in a long and winding journey through New York after 9/11
At the Movies
David Lynch: 10 reasons to worship himIt's time to celebrate director David Lynch as the BFI screens a season of his films.
Movies Interviews
Max von Sydow 'Extremely Loud' interviewActing legend Max von Sydow on Extremely Loud & Incredibly Close, The Exorcist and Flash Gordon.
Box Office Charts
'The Woman in Black' wins UK box officeThe Woman in Black beats The Muppets and Star Wars at the the UK box office.
