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The filmmaker signed on in January to update the Jules Verne novel that was turned into a classic 1954 Disney movie featuring James Mason as the captain of the Nautilus submarine.
The Terminator Salvation helmer had previously suggested that he was hoping actor Will Smith would take on the role for his origin picture.
However, McG told IGN that he would love to reteam with Worthington, who co-starred with Christian Bale in the recent sci-fi blockbuster.
He said: "I take a lot of satisfaction in playing a role in breaking the great Sam Worthington, who I think is one of the best actors out there. He's all over the place, and I might cast him as Nemo if it's in the cards. We'll see."
McG is also attached to direct the film adaptation of stage musical Spring Awakening.
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