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The actor had been suggested to be taking over the role - previously played by Tom Cruise and Stuart Townsend respectively - under a Universal Pictures reboot of the franchise.
Rice could not confirm nor deny if the rumour about the star's casting was true. However, if he does sign on to portray the 18th century bloodsucker, she said that he has her approval.
"I can say without hesitation that I love Robert Downey Jr and I think he would make a fabulous Vampire Lestat," she told BSC. "He is a major actor, a powerhouse of talent and personality, and he evinces an irrepressible and seductive charm.
"He would bring great energy and skill to the role. I would love to see this happen."
It is unknown which novel the studio plans to adapt, while Rice's Interview with the Vampire was made into a movie in 1994, followed by Queen Of The Damned in 2002.
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