The Broken Embraces star, who has worked with the director since she was 17 years old, has said that she will always love working with him.
Cruz told The Times: "For him, it's not like, 'Today we will shoot a big scene'. Everything is treated with the same intensity. That's the way it should be, every day should feel like the first day of shooting, because even if you have been rehearsing for months like we do, it is still abstract until you start filming.
"I like this. It's addictive too: everything is constantly changing, the energy of your fellow actors and director affects you. It's very alive."
The 35-year-old actress has also revealed that despite the numerous films that the pair have collaborated on, she never finds herself too relaxed on his sets because she fears that she might disappoint the iconic Spanish filmmaker.
She said: "Some people ask me that, because we are friends and I have known him for so many years, maybe I am more relaxed on set with him.
"It is the opposite, because he is someone very important in my life and career as an actress and because he has given me really great opportunities. So I never want to disappoint him. That would make me feel really sad."
Almodovar, who is openly gay, has recently admitted that his muse Cruz was the first woman to ignite a "sexual desire" in him.
Broken Embraces is currently in cinemas in the UK and is to be released in the US on October 11 for the New York Film Festival.