The Two And A Half Men star will reprise his Bud Fox role in a cameo capacity, the director told The New York Times.
In the original film, the 44-year-old played a young stockbroker who ultimately brings down Michael Douglas's Gordon Gekko but must atone for his own shady dealings with the financier.
Stone also confirmed reports that the story will begin 22 years after the first ended.
"When Gekko comes out of prison in the beginning of this movie, he essentially has to redefine himself, redefine his character," he said. "He's looking for that second chance."
Money Never Sleeps will also feature Shia LaBeouf, Josh Brolin and Frank Langella.
The follow-up will begin filming this week in New York City and is released in April 2010.
It was previously reported that Susan Sarandon has joined the cast as LaBeouf's mother.