The film revolves around a wealthy father who takes his two daughters on a trip to find his wife's lover in the hope that it will keep his family together.
Based on the debut novel by Kaui Hart Hemmings, Descendants marks Payne's first film since 2004's Oscar winner Sideways. Production is scheduled to start in February in Hawaii.
Clooney can be seen as a psychic government spy in comedy The Men Who Stare At Goats from this Friday. He is also the voice of the title character in Wes Anderson's Fantastic Mr Fox movie.