Julia Roberts will lend her voice to the the main character in the upcoming animated and live-action adaptation of children's book Charlotte's Web.

The Closer actress will play Charlotte, a spider who tries to save her porcine friend Wilbur with the help of a little girl.

The film, adapted from the E.B. White book, will also feature Python John Cleese as a sheep, chat-show host Oprah Winfrey and Pulp Fiction's Steve Buscemi as a rat.