In his most recent Cup O' Joe blog, Quesada was asked about rumours that Kenneth Branagh's forthcoming adaptation would be a flop.
Quesada promised that Thor will offer fans something more than any other movie of that genre has done before.
"People are going to go into this movie with a preconceived idea about what it will be," he said. "If you're a comics fan, you'll have a preconceived notion of what you're going to get. If you're a non-comics fan, you'll have another notion of what the movie is all about.
"And what's really amazing is that both groups will walk away going, 'I've never seen anything like this before within the superhero genre'. It's so cool, and I don't want to use the word unusual, but it is unusual in the sense that it redefines what a superhero movie can be.
"It's not the expected story or settings. That part of it is incredibly exciting to me."
Nick and Norah's Infinite Playlist star Kat Dennings was the latest actor to be confirmed for the film. She will play Darcy, a co-worker of Natalie Portman's character Jane Foster.