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The New Moon star told Parade that the pair had a lot of fun while making the Jason Reitman-directed picture.
Kendrick said: "There was a lot of goofing around and there were definitely days were I felt like Clooney was the teenager and I was the mum.
"I was like, 'George come on, I'm trying to focus', which was a very strange thing to be saying to George Clooney.
"But he would be playing with Nerf balls on set, so I was trying to dodge Nerf balls while getting prepared for a scene."
She added: "Sometimes, George gave me a really hard time. He was always kidding around about me being in New Moon because I was shooting that at the same time.
"I decided that entitled me to give George a hard time right back. I think I made fun of him a lot more than I ever realised I would.
"Like he'd call me short and I'd call him old. If you'd told me before I did the film that I would be making fun of George Clooney that way I wouldn't have believed you."
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