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Rex Features
The Moonstruck helmer will receive the prize at the 62nd annual DGA Awards on January 30 at the Century Plaza, LA.
Jewison will be the 33rd artist to be handed the gong. Past recipients include Alfred Hitchcock, Orson Welles and Steven Spielberg.
"He is an incredible filmmaker whose calm, affable manner belies a ferocious creative fire within," said DGA president Taylor Hackford.
He added: "There are very few filmmakers whose body of work moves so fluidly between romantic comedy and political thriller, musical and satire, with an ease and an eloquence that few could hope to match."
Jewison has been nominated for four Oscars and his films have received 12 Academy Awards.
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