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The project, formerly named I'm With Cancer, is based on Will Reiser's autobiographical account of his battle with the disease in his 20s.
Kendrick, who can next be seen opposite George Clooney in Up In The Air, will play an inexperienced psychologist assigned to handle the lead character's case.
The Wackness director Jonathan Levine has replaced Nicole Holofcener at the helm of the project, which will begin shooting in Vancouver next month.
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