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The former Samantha Who? lead is in negotiations to appear alongside Owen Wilson, Jason Sudeikis and Jenna Fischer in the New Line project, reports Deadline Hollywood.
The 38-year-old is eying the role of a wife who gives her husband a "hall pass", or the chance to sleep with another woman without consequence.
Applegate will next be seen in the romantic comedy Going The Distance, scheduled to open in US cinemas October 8.
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