Rex Features
The former Charmed cast member joins the already cast Christina Applegate, Owen Wilson, Jason Sudeikis and Jenna Fischer in the New Line project, says The Hollywood Reporter.
The film centres on wives who give their husbands the chance to sleep with other women without consequence.
The movie, scripted by Bobby and Peter Farrelly, also stars Amanda Bynes, Stephen Merchant and J.B. Smoove.
Milano will next be seen in the ABC comedy series Romantically Challenged.
