Alice's £7.3 million haul is more than double runner-up Shutter Island's $2.25 million, while Matt Damon's Green Zone debuts in third place with just over $2 million in ticket sales.
James Cameron's Avatar slips to fourth spot in its third month on release, while Richard Gere's dog tragedy Hachi is a new entry at five.
Elsewhere, Swedish thriller The Girl With The Dragon Tattoo makes an impressive debut, bowing at number six with close to £400,000 in box office receipts.
The UK box office top ten in full:
1. (1) Alice In Wonderland - £7,343,506
2. (-) Shutter Island - £2,250,178
3. (-) Green Zone - £2,087,368
4. (2) Avatar - £638,599
5. (-) Hachi: A Dog's Tale - £442,753
6. (-) The Girl With The Dragon Tattoo - £378,434
7. (4) The Lovely Bones - £343,385
8. (3) The Crazies - £252,353
9. (5) The Princess And The Frog - £223,125
10. (7) Percy Jackson And The Olympians - £195,262