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According to The Hollywood Reporter, Phase 4 Films is to release the Alex De Rakoff-helmed action thriller later this year.
Tamer Hassan, Danny Dyer, Brenda Blethyn and Monet Mazur also star in the story of an ex-con (Hassan) given 24 hours to pay back a loan shark played by the rapper.
"Dead Man Running is a heart-pounding, fast-paced adrenaline rush with 50 Cent, who once again proves how multitalented he is, adept in crossing over from music to movies," said Phase 4 president and CEO Berry Meyerowitz.
Phase 4 also acquired the US theatrical rights to Brigitte Berman's documentary Hugh Hefner: Playboy, Activist and Rebel, the Sundance indie The Freebie and the romantic comedy Finding Bliss.
