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Previous recipients include John Waters and Guy Madden.
According to The Hollywood Reporter, the Clerks director will accept the award at the festival, which runs June 16 to June 20 in Provincetown, Massachusetts.
The event will also honour Tilda Swinton with its 'Excellence in Acting' award as well as the directing partners Rob Epstein and Jeffrey Friedman with its 'Faith Hubley Memorial' award.
"We are thrilled with these four award recipients. They each represent the spirit and artistic voice of what independent filmmaking is today," said event executive director Gabby Hanna.
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