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Van Damme will join Gary Oldman, Jack Black and Dustin Hoffman in the sequel, DreamWorks Animation has announced.
The Universal Soldier star will play Master Croc.
Michelle Yeoh and Victor Garber have also joined the voice cast, which includes Angelina Jolie, Seth Rogen, Lucy Liu, James Hong and David Cross.
The follow up is scheduled to open May 27, 2011 in US cinemas.
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