© Rex Features
Superhero Hype confirmed the news at a press junket yesterday for Mendes's new film The Other Guys.
"No, unfortunately," was Mendes's response to whether she would be reprising her role as Cage's love interest Roxanne Simpson in the tentatively titled Ghost Rider:Spirit of Vengeance, due to begin filming this November.
It is unknown at this stage whether the part of Roxanne will be recast or if the studio will instead use another female character from Marvel's Ghost Rider comic book series.
Cage confirmed in July that he will reprise his role as Johnny Blaze aka Ghost Rider in the update, which Mark Neveldine and Brian Taylor are reportedly in negotiations to direct.
