Along with the previously announced Never Let Me Go and 127 Hours, Natalie Portman's ballet thriller Black Swan and new films from directors Mike Leigh (Another Year), Anton Corbijn (The American), Ken Loach (Route Irish) and Jean-Luc Godard (Film Socialisme) will all screen at the festival.
Cloverfield helmer Matt Reeves's Let Me In, a remake of the critically acclaimed Swedish horror Let The Right One In, will make its UK debut at the two-week festival.
Colin Firth's The King's Speech and Annette Bening's The Kids Are All Right - two films that have already been touted for Oscar nominations next year - are in the lineup, as is Will Ferrell drama Everything Must Go, Kaboom, It's Kind Of A Funny Story, East Is East sequel West Is West and Richard Ayoade's directorial debut Submarine.
Among the other 197 feature films screening are Africa United, Hilary Swank's Conviction and Olivier Assayas's Carlos.
Uncle Boonmee Who Can Recall His Past Lives, which scooped the Palm d'Or at the Cannes Film Festival earlier this year, will also be showcased.
The BFI London Film Festival will run from October 13 to 28.
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