The actor, who has previously voiced his apprehension about returning for a third Ghostbusters film, wore a boiler suit and replica proton pack as he accepted the 'Best Horror' prize for Zombieland.
The event, which pays tribute to horror, sci-fi, comics and fantasy, saw Michael J. Fox and Christopher Lloyd receive a standing ovation as they reunited with a DeLorean car to mark the 25th anniversary of Back To The Future.
Fox recently recreated the Back To The Future teaser trailer to promote the Scream Awards.
Sigourney Weaver also accepted the special 'Heroine' award from her Aliens and Avatar director James Cameron.
A 90-minute highlights show of the Scream Awards will air tomorrow night on Spike TV.