The play, which is currently in previews at the National Theatre, stars Jonny Lee Miller (Trainspotting) and Benedict Cumberbatch (Sherlock) alternating the role of Victor Frankenstein and The Creature.
Frankenstein will be broadcast live via satellite in high definition in 370 cinemas worldwide on March 17. A second show will screen across the UK and Europe on March 24 so that audiences can compare the performances of Miller and Cumberbatch.
Boyle, whose latest movie 127 Hours earned a 'Best Picture' Oscar nomination, will hold two camera rehearsals and have up to eight cameras running on the night of the live cinema transmissions.
The National's head of digital media David Sabel said of bringing the stage performances to the big screen: “Our biggest problem is always, how can we make this exciting to watch rather than just have one static camera at the back?
"We’re not making a movie, it’s very much the live experience. This doesn’t feel like a piece of theatre that’s being restaged for the cinema - you feel incredibly connected to the live performance. Our US audience is growing quite dramatically."
Frankenstein's initial ten-week run in London has already sold out, but has been extended until early May with tickets yet to be made available.
> Click here to watch our recent interview with Danny Boyle