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Marshall-Green, who starred on the TV series The O.C., will play a love interest for Noomi Rapace's character, according to Shock Till You Drop.
Michael Fassbender, Charlize Theron, Idris Elba, Sean Harris and Kate Dickie also star in the film.
Marshall-Green most recently starred in the M. Night Shyamalan-produced movie Devil.
Prometheus is scheduled to open in theatres on June 8, 2012.
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