The novel, first published in 2001, takes place in a world in which gods and mythological creatures exist.
In a recent interview, Gaiman exclusively revealed to DS that a director "who has many, many Oscars" is already on board the project.
"I'm going to be having a meeting in LA with the people that the film rights have been sold to," he confirmed. "I'm going to be... talking to them, find out where they're going and if there's any way that I can help."
He also described the unnamed director attached to the film as "a genius".
"He fell in love with this [novel] about six or seven years ago and has not given up," explained the writer.
Watch Neil Gaiman discuss the upcoming American Gods film in full below.