The couple met on the set of Slumdog Millionaire, where Pinto said that they formed a connection even their families couldn't understand.
However, Pinto told You magazine that she wouldn't want to work with Patel again because it would be impossible to recapture that initial chemistry.
"I wouldn't want to work with him, but I don't mean that in a bad way," said Pinto. "[Dev] said something similar in an interview that was misinterpreted.
"What he was trying to say was that so much happened on Slumdog Millionaire, in terms of it becoming so big, that if the two of us were paired in a film as a couple again it wouldn't live up to that. Nothing ever could. It's too much magic to live up to on screen."
The actress added that she finds it difficult to cope with the media attention surrounding her relationship. "I am fine with them when I am working or promoting a film, but they get annoying when the two of us are together," she said.
"There is double the interest and that's sad because you realise it's not about the work, it's about the gossip."
Pinto, who has previously spoken of the problems of having a long distance relationship between London and India, also gave some insight into how the couple make it work.
"It's about respecting each other's work and respecting the relationship," she said. "We have to think, 'OK, you are working there and I am working here but we are going to have to make time for each other.' "