The actress, who played Lucille in the first movie, admitted to DS that "everyone always asks" about the potential sequel.
Gugino said that co-directors Robert Rodriguez and Frank Miller "really want" to make the follow-up to the 2005 adaptation of Miller's comics.
"It seems there's a possibility that it will actually happen," she said. "But it's about timing for so many people on that one, so we shall see."
Rodriguez recently confirmed that he would like to cast Bruce Willis in the movie, after previously revealing that he has been rewriting the script for the film.
Watch our Carla Gugino video interview below:
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