According to Deadline, Polish has cast Jean-Marc Barr, best known for his work in the films of Lars von Trier, as the film's lead role of Jack Kerouac himself.
Joining Barr will be Sweet Home Alabama lead Josh Lucas as Beat Generation muse Neal Cassady, and former Lois Lane Kate Bosworth as the two characters' love interest, Billie.
Big Sur follows Kerouac's alter ego Jack Duluoz as he moves from New York to California in an attempt to rebuild his life after struggling in the wake of the success of his acclaimed novel On The Road.
The film will also feature former Brothers & Sisters regular Balthazar Getty, ex-ER star Anthony Wards and The Crazies actress Radha Mitchell.
Walter Salles recently completed filming on a film adaptation of On The Road, starring Control actor Sam Riley opposite an all-star cast including Kristen Stewart, Kirsten Dunst, Garrett Hedlund and Viggo Mortensen.
Polish will both write and direct Big Sur, although a release date has yet to be announced.