The Jennifer's Body star could take on the role of a son who is called to his eccentric mother's bedside in the prosperous town of Connecticut, The Wrap reports.
Susan Sarandon and David Arquette are also in talks for the film, which is penned by Jenna Carta and Mandy Steckelberg.
The Thelma and Louse actress is in line to play the mother, with Arquette in the role of a nearby bar owner.
Rosanna, who is best known for Desperately Seeking Susan, has previously helmed the documentaries All We Are Saying and Searching for Debra Winger.
Brody can currently be seen in Scream 4, alongside David Arquette, who reprises his previous part in the horror franchise.