Sudeikis will become the ninth cast member from the long-running comedy show to compère the awards ceremony. The actor's role was confirmed by Ryan Seacrest on his On Air radio show.
Sudeikis's other screen credits include Hall Pass, Going the Distance and 30 Rock.
Previous hosts for the MTV Movie Awards include Aziz Ansari, Sarah Silverman, Jessica Alba and Lindsay Lohan.
Voting is currently open across 13 movie categories - including 'Best Kiss', 'Best Fight' and 'Best 'Villain' - on MTV.com.
The MTV Movie Awards will be broadcast on MTV, Sunday, June 5, from the Gibson Amphitheatre in Universal City, California.