Summit Entertainment produced the Twilight films.
Tsotsi and X-Men Origins: Wolverine director Gavin Hood is helming the sci-fi film project, based on the novel by Orson Scott Card.
Ender's Game tells the story of Andrew 'Ender' Wiggins, a young boy who trains in the art of war in order to fight off an alien invasion by an insectoid race. Ender is revealed to be a tactical genius.
Wolfgang Petersen was previously attached to helm the project, but the director left the production in April 2008.
Odd Lot Entertainment hired Hood last September, and Star Trek scribes Alex Kurtzman and Roberto Orci joined as producers in January.
The adaptation will be shopped at the upcoming 2011 Cannes Film Festival, reports Deadline.