The actor will take on the role of a layabout member of the Collins family, who occupy a rambling estate once owned by cursed patriarch-turned-vampire Barnabas, played by Johnny Depp, Collider reports.
He will join Michelle Pfeiffer, Eva Green, Chloe Moretz and Burton regular Helena Bonham Carter.
Warner Bros. teased more details of the plot, which is inspired by the cult US programme of the same name created by Dan Curtis, which ran between 1966 and 1971.
Depp's character will wake up in 1972 after being buried alive by a scorned witch in 1752, only to find that the Collins clan are divided and in therapy.
Burton is helming from a script by Pride and Prejudice and Zombies novelist Seth Grahame-Smith.
Dark Shadows will open in cinemas on May 11, 2012.
Miller will next be seen in a Channel 4 documentary on the production of Danny Boyle's stage adaptation of Frankenstein.