Kate Beckinsale, Jessica Biel and Bryan Cranston are already signed for the remake of the 1990 film, which starred Arnold Schwarzenegger and Sharon Stone.
Nighy will take on the role of Quatto, the leader of the resistance against the oppressive government, according to The Hollywood Reporter.
Wiseman's version has returned to Philip K. Dick's source material, with Colin Farrell in the lead as the factory worker who believes he is a spy but does not know whether he is employed by his own nation state or a neighbouring hostile one.
Farrell has revealed that the remake will be much darker than the original film helmed by Paul Verhoeven.
Ethan Hawke is to make a cameo appearance in Total Recall.
Watch the trailer for the original Total Recall below: