The A Better Life filmmaker, who helmed the second movie in the vampire romance franchise, suggested that the fan hysteria created by stars Robert Pattinson, Taylor Lautner and Kristen Stewart was akin to Beatlemania.
Weitz told Digital Spy that the amount of screaming from Twilight fans will "haunt him forever".
"I remember going to the Munich Olympic Stadium and there were 23,000 young women screaming. It wasn't for me, I was only the Ringo Starr at best of the whole quadruplet that was travelling," he said.
The director also recalled being unable to go to the bathroom during filming in a small Italian town because the location was overrun with fans of Stephenie Meyer's fantasy saga.
"When we were shooting our final four days in Montepulciano in Italy, because it was known that we were shooting there every day, thousands and thousands more young girls would show up - until the point where the streets were jammed, we couldn't get our equipment from one location to another," he explained.
"I couldn't go to the loo because every cafe, every restaurant was just packed. So I just held it!"
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Watch Chris Weitz discuss his experiences making Twilight: New Moon below: