The You Don't Mess with the Zohan star will portray the vampire in the forthcoming animated comedy from the creators of Cloudy with a Chance of Meatballs.
Hotel Transylvania follows Dracula as the owner of a hotel that monsters and their families can enjoy together without having to worry about interference from humans. However, the establishment is jeopardized when a normal person accidentally wanders in.
"We're thrilled to be working with Adam to create a comedic Dracula for a new generation," said Sony Pictures Animation's president of production Michelle Raimo-Kouyate.
"We have a unique story about that iconic character... that re-imagines Transylvania and its legendary monsters in the way that only animation can."
Sandler received his own star on the Hollywood Walk of Fame in February.
Earlier this year, the actor revealed that he employs a transgender housekeeper after he began to get frustrated by his female-filled household.
Sandler has two daughters with his wife Jackie.