Matt Damon, Gwyneth Paltrow, Jude Law and Kate Winslet are among the A-list cast for the movie, which centres on a deadly airborne virus that spreads rapidly across four continents. Contagion's interconnecting plotlines will reportedly evoke the style of Soderbergh's Oscar-winning drama Traffic.
Marion Cotillard, Laurence Fishburne, Elliott Gould, John Hawkes and Bryan Cranston are also among the cast for Contagion, which opens in cinemas this October.
Soderbergh will allegedly retire from directing after his big-screen remake of '60s spy show The Man From U.N.C.L.E. with George Clooney.
Watch the Contagion trailer below: