According to Bang Showbiz, the Mad Men actress has been cast in an unknown role in the movie, directed by Brian Dannelly.
Glee star Colfer wrote the film's script, and will portray the lead role opposite the likes of Dermot Mulroney, Sarah Hyland, Angela Kinsey and Polly Gergen.
"We're so thrilled to begin filming this story that really captures the trials and tribulations of coming into your own," Dannelly explained. "We're got a phenomenal cast on board and Chris's script is so smart, fresh and funny, but also has such heart.
"I'm excited to help tell this coming-of-age story that I think will resonate with young audiences, and all of us who've survived adolescence."
Earlier this month, Hendricks was nominated for an Emmy Award for 'Best Supporting Drama Actress', while Colfer himself was nominated in the 'Best Supporting Comedy Actor' category.
Principal photography on Struck by Lightning has already begun, although a release date has yet to be announced.