The final instalment in the magical franchise smashed the previous totals for three-day weekend takings, the biggest Friday and Saturday results and greatest single-day figures.
All four records were last held by the film's predecessor, Deathly Hallows: Part 1, which grossed £18.3m in its first weekend last year. Part 1 still holds the biggest Sunday takings, though Part 2 could also achieve this feat when its final figures are released.
In the US, Deathly Hallows: Part 2 broke The Twilight Saga's records for first-day takings and midnight screenings, held by New Moon and Eclipse respectively.
It topped the US box office yesterday after grossing $168.5m (£104.6m) to beat The Dark Knight's opening weekend record from 2008.
Harry Potter and the Deathly Hallows: Part 2 has so far made approximately $475.6m (£292.9m) worldwide, according to Warner Bros.
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> 'Harry Potter Deathly Hallows: Part 2' - Watch the world premiere
Watch the trailer for Harry Potter and the Deathly Hallows: Part 2 below: