The Doug Aarniokoski-directed film stars Boardwalk Empire actress Paz de la Huerta as a nurse who leads a double life, punishing and torturing dishonest men.
According to Variety, Bleu has been cast opposite de la Huerta and co-star Katrina Bowden as a paramedic who becomes involved in the nurse's sadistic games.
Nurse 3D was inspired by the still imagery of horror photographer Tim Palen, whose work explores notions of care-giving and punishment.
Bleu was most recently seen on stage as Usnavi in the Tony Award-winning Broadway play In The Heights.
Earlier this year Bleu was linked to The X Factor USA as a potential host until the job eventually went to English presenter Steve Jones.