30 Minutes or Less star Eisenberg explained that it felt odd to be competing against other actors for the coveted trophy.
"It's a stressful experience. It feels like a lose/lose situation," American-Statesman quotes him as saying. "If you win, you have to make a speech, and that can go wrong, like you don't thank the right person. And if you lose, you lose."
Eisenberg added: "I [also] don't like dressing up. I feel like a child. I just feel stupid. I don't want to seem ungrateful. It's just that I have a pessimistic way of looking at things."
The actor will next appear in Woody Allen's upcoming film The Bop Decameron, which is currently filming in Rome.
Eisenberg declined to reveal any of The Bop Decameron's plot details, but did praise Allen as "the greatest director of all time" and listed the filmmaker's Annie Hall and Hannah and Her Sisters among his favourite movies.
30 Minutes or Less, starring Eisenberg and Danny McBride, is now playing in US cinemas and is released on October 16 in the UK.
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Watch the 30 Minutes or Less trailer below: