Longoria has played main character Gabrielle Solis since the show began back in 2004, but will move straight into several new roles when the series ends next year.
According to Variety, Longoria has landed a supporting role in the indie drama Long Time Gone opposite Meg Ryan.
The actress has also signed on for the lead role in Who Gets the Dog?, an indie comedy about a separated couple fighting for custody of their beloved pet.
Longoria has also been cast opposite Brendan Fraser in Four Kings, a historical drama set during the French and India war.
Finally, Longoria will voice the lead in a new Hulu animated series called Child Support, playing an irresponsible mother described as being similar to Peter Griffin in Family Guy.
Earlier this month, Desperate Housewives creator Marc Cherry confirmed that the show will come to an end after its eighth season.
Desperate Housewives will return for its final season on ABC on September 25.
Watch the trailer for season seven of Desperate Housewives below: