50/50 was written by Will Reiser and centres on Kyle (Joseph Gordon-Levitt), a 27-year-old diagnosed with the illness, a story based on Reiser's real life. Rogen plays Adam, Kyle's friend who helps him cope with the struggles surrounding his condition.
Talking to MTV News, Rogen said that while the film deals with a rather heavy issue, the approach is almost light-hearted and still "really, really funny".
"It is about something somewhat serious, but I really think it's as funny as any of our movies. That's what is really interesting about it to me. We'd always talk about how it's not a creative challenge to take something depressing and make something depressing out of it," he explained.
"To us, it was much more interesting to take something that's inherently depressing and try to make something really, really funny out of it. To me, the movies that are about something you generally don't want to watch but you keep watching for decades to come, the only reason you do that is because they're funny."
Rogen went on to compare 50/50 to the cult classic Dr. Strangelove, adding: "No-one wants a movie about f**king nuclear war, but if it's funny, you keep watching it. Tonally, that's what we were trying to do."
Co-Star Bryce Dallas Howard has said that the film is "truthful" about the realities of cancer.
Watch the trailer for 50/50 below: