Seth Rogen has revealed that the pair are playing cameo roles in the comedy horror film, the details of which were announced last year by co-star Jay Baruchel.
"It's a very strange movie, but it's gonna happen. It's all our friends, luckily, and we all play ourselves in the movie," Rogen told PA.
"I literally play Seth Rogen in the movie and Jay Baruchel literally plays himself in the movie and others - Jonah Hill, James Franco - they're literally playing themselves in the movie."
Of the movie's plot, Rogen added: "They think they've kind of survived the worst and then they realise they all really can't stand to be around each other as they're stuck in this house together."
Jay and Seth vs. The Apoclaypse, is based on a comedy skit written by Rogen and Evan Goldberg that appeared on YouTube last year.
Watch the trailer for Jay and Seth vs. The Apocalypse below (adult content):