The movie began as a prequel to Scott's '70s classic Alien but was later changed to an "original science fiction epic".
Weaver told Outbreak Hollywood: "I actually talked to Ridley about this very idea, and I'm delighted he's doing it. I feel it's in good hands. It's a wonderful franchise and if they can invigorate the creature, it could have another life.
"I do think that Alien was ahead of its time. It makes me laugh because it's not like… our producers were lovely men, and Ridley Scott too. But they weren't being feminists. They thought the last person that anyone would think would survive is this girl. So it was really done for the story, not for any political, feminist reason."
Writer Damon Lindelof explained the connection between the new film and the classic sci-horror franchise in June.
Weaver - who will next be seen in Abduction - has also been in talks for a third movie in the Ghostbusters series.
She said recently that she does not think the original cast can commit to another sequel unless Bill Murray decides to reprise his role.
Prometheus is released March 9, 2012.
Watch the trailer for Abduction below: