The Twilight, Transformers: Dark of the Moon and RED producers will adapt the four-issue Image Comics series into a movie, reports Deadline.
Area 52 is a top-secret storage facility in Antarctica, used as a dumping ground for unwanted alien technology.
Brian Haberlin and Clayton Henry's miniseries follows the adventures of the facility's rag-tag employees, who must band together when an extraterrestrial killing machine is set loose.
Lorenzo di Bonaventura and Mark Vahradian will produce Area 52, and Benderspink's JC Spink will be executive producer.
Benderspink most recently executive produced I Am Number Four and The Hangover Part II.